The term "the munchies" refers to a person's tendency to nibble when under the influence of marijuana. As a result of these immediate appetite-enhancing effects, numerous experts believe that marijuana may help cancer and HIV patients gain weight. However, other investigations have shown that weight gain is not necessarily clinically relevant in certain medical conditions, despite the fact that hunger may be enhanced. To get a medical marijuana card follow the link.
On the other hand, when weight gain did occur in a trial of cancer patients, it was smaller than that of the comparison medicine (megestrol). However, it is widely accepted that marijuana usage has a positive effect on appetite, particularly in those who are underweight. When it comes to big epidemiological studies of the general population, results show that marijuana users have lower BMIs than non-users on a constant basis. Some study confounds may help explain these results, which are paradoxical and puzzling, such as the potential differences between acute and chronic marijuana use, the tendency for marijuana use to be linked to other forms of drug use, and/or the possible competition between food and drugs for the same reward sites in the brain. If marijuana is a metabolic regulator, it may raise body weight in people who are underweight, but not in those who are normal weight or overweight. Alternatively, the effects of marijuana may be influenced by the person's beginning weight status. Only further in-depth studies will shed light on the nuanced interactions between marijuana use and weight gain. To access medical marijuana doctors orlando follow the link.
Cannabis, cancer, HIV, tetrahydrocannabinol, tetrahydrocannabinol effects on body weight
Psychiatry and general care are inextricably intertwined, and this column is devoted to the difficult clinical interaction between the two areas.
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INTRODUCTION
Acute marijuana usage has been shown to temporarily increase hunger and nibbling, a phenomenon known as "the munchies." "Gettin' Da Munchies" is a good illustration of this occurrence in the film. An intergenerational video gaming tournament is organized by the film's protagonist and many of his pals. His intentions go astray and he ends up smoking marijuana for the first time because of his irritation, which causes him to have the munchies. At all times, the protagonist is on a constant and desperate hunt for nourishment. Is there a longer-term link between marijuana usage and weight gain beyond only the short-term impact on appetite? Examine these probable correlations via the literature in this episode of The Interface.
Prior to evaluating the limited available empirical data, we first discuss the known physiological effects of marijuana on the control of hunger and body weight. To find medical marijuana doctors st. petersburg follow the link.
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CARNABINOID IMPACTS ON APPETITE AND WEIGHT REGULATION, A CLINICAL STUDY
Cannabinoids, as well as endocannabinoids, which activate cannabinoid receptors in the body, seem to have a direct impact on the control of eating behavior in the brain and body. This conclusion is empirically supported by Vemuri et al1, who find evidence for the role of endocannabinoids as major biomediators and metabolic regulators in mammalian physiology, including the control of body weight. The CB1 and CB2 receptors, which are mostly found in the brain and immune system, are the most important endogenous cannabinoid receptors in mammals. 2 Some CB1 receptors are found in the stomach and intestinal tissue in addition to their primary sites in the brain (e.g. hypothalamus, limbic forebrain). 3 Agonism of CB, receptors has been shown to elicit a desire to eat. 3 As stated by Kirkham,4 activation of the CB, receptors in the mammalian cannabinoid system primarily stimulates food cravings as well as adipose tissue formation.
In line with this paradigm, researchers have been investigating the effects of antagonizing CB receptors in an attempt to curb eating behavior in recent years. In theory, the
Cannabinoid receptor antagonism may result in decreased calorie intake and weight reduction. Pharmacological blockage of the CB receptor causes normal weight growth to be inhibited, eating behavior to be lowered, and food intake to be suppressed, as expected, in rats and mice in empirical studies.5
It is likely that CB1 receptor antagonists might be used to treat weight problems such as obesity because of their therapeutic effects in animal research.
8 Rimonabant, a CB1 receptor antagonist, and taranabant, a Phase III CB1 receptor antagonist, were both tested on obese European study participants, and the results were dismal. 2 Participants on these pharmacological therapies lost weight, although their weight reduction was not greater than that obtained by conventional anti-obesity drugs. Rimonabant and taranabant have also been linked to an increased risk of suicidal thoughts and other serious side effects in clinical trials, according to the researchers. 9,10 CB antagonists such as these satisfied the scientific vision that they could reduce body weight, but they did not have the desired effect. To find medical marijuana doctors in florida go to the listed website in the link.
Because of this prelude, the connection between marijuana and weight reduction seems to be straightforward: stimulation of CB receptors promotes weight gain, whereas antagonism of CB receptors causes weight loss.. There are, however, some startling results from research on marijuana usage and weight gain.
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MARIJUANA USE AND CALORIE INHALED BY NORMAL PEOPLE
Low amounts of marijuana (e.g., a single cigarette) had no influence on food consumption, according to a research in healthy participants.
11 Increased food consumption between meals rather than an increase in the amount of meals is the primary cause of increased caloric consumption from marijuana use (e.g., two or three smokes per day). 11 With this discovery, a foundation is laid for future studies including HIV-positive cancer patients, who are expected to make up the majority of the research conducted in this field. Marijuana has been shown to increase hunger in both animal and human studies. To find medical marijuana doctors follow the link.
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Patients with HIV/AIDS and marijuana use and body mass
A research by Haney13 indicated that both oral and smoked cannabis were beneficial in enhancing food intake among HIV-infected individuals. University of California researchers found that patients with HIV or AIDS who received either smoked marijuana or dronabinol (an FDA-approved oral medication that contains the same active ingredients as marijuana) gained more weight than those who received placebo in a study comparing the two active treatments (AIDS). 14 Researchers found that those who took either marijuana or dronabinol (or a placebo) gained an average of 3.51 pounds of weight during the course of the trial. Researchers found that both marijuana and dronabinol significantly increased food consumption in HIV-positive marijuana users, according to Haney et al15. Dronabinol has been shown to enhance calorie intake in HIV-positive marijuana users, however repeated administration seems to result in a resistance to these effects. Most of these studies had tiny samples, which was an important consideration.